Residual force enhancement in myofibrils and sarcomeres
نویسندگان
چکیده
منابع مشابه
Residual force enhancement in myofibrils and sarcomeres.
Residual force enhancement has been observed following active stretch of skeletal muscles and single fibres. However, there has been intense debate whether force enhancement is a sarcomeric property, or is associated with sarcomere length instability and the associated development of non-uniformities. Here, we studied force enhancement for the first time in isolated myofibrils (n=18) that, owin...
متن کاملResidual Force Enhancement in Mechanically Isolated Half-sarcomeres
Our goal was to test if half-sarcomeres produce force enhancement after stretch. Single myofibrils from rabbit psoas were placed in a temperature-controlled (10°C) bath, where half-sarcomeres were isolated using two precalibrated glass micro-needles. The force produced during activation of the half-sarcomere was measured by tracking the displacement of the micro-needles. The half-sarcomere leng...
متن کاملThe role of sarcomere length non-uniformities in residual force enhancement of skeletal muscle myofibrils.
The sarcomere length non-uniformity theory (SLNT) is a widely accepted explanation for residual force enhancement (RFE). RFE is the increase in steady-state isometric force following active muscle stretching. The SLNT predicts that active stretching of a muscle causes sarcomere lengths (SL) to become non-uniform, with some sarcomeres stretched beyond actin-myosin filament overlap (popping), cau...
متن کاملA Mathematical Model of Muscle Containing Heterogeneous Half-Sarcomeres Exhibits Residual Force Enhancement
A skeletal muscle fiber that is stimulated to contract and then stretched from L₁ to L₂ produces more force after the initial transient decays than if it is stimulated at L₂. This behavior has been well studied experimentally, and is known as residual force enhancement. The underlying mechanism remains controversial. We hypothesized that residual force enhancement could reflect mechanical inter...
متن کاملMuscle residual force enhancement: a brief review
Muscle residual force enhancement has been observed in different muscle preparations for more than half a century. Nonetheless, its mechanism remains unclear; to date, there are three generally accepted hypotheses: 1) sarcomere length non-uniformity, 2) engagement of passive elements, and 3) an increased number of cross-bridges. The first hypothesis uses sarcomere non-homogeneity and instabilit...
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ژورنال
عنوان ژورنال: Proceedings of the Royal Society B: Biological Sciences
سال: 2008
ISSN: 0962-8452,1471-2954
DOI: 10.1098/rspb.2008.0142